As the HVAC industry continues to shift away from ozone-depleting refrigerants like R-22, finding a reliable, efficient, and EPA-compliant replacement is more critical than ever. One standout alternative gaining popularity is R-422B, also known as NU-22B. If you're looking for a drop-in refrigerant that’s easy to handle and delivers high performance, the R-422B 25 lb (NU22) Refrigerant New Factory Sealed Cylinder available at Royal Refrigerants is a smart investment.

In this blog post, we’ll cover everything you need to know about R-422B—from its benefits and compatibility to storage tips and how it compares with other R-22 replacements. Whether you're an HVAC technician, contractor, or facility manager, this guide will help you make an informed decision.

What Is R-422B Refrigerant?

R-422B, also marketed as NU-22B, is a non-ozone-depleting hydrofluorocarbon (HFC) refrigerant blend. It was developed specifically to replace R-22 in existing air conditioning and refrigeration systems.

✔ Chemical Composition: R-422B is composed of R-134a, R-125, and Isobutane (R-600a).
✔ Blend Type: It’s a zeotropic blend, which means it has a temperature glide and must be charged as a liquid.
✔ Classification: A1 – Non-toxic and non-flammable.

R-422B is a “drop-in” replacement, which means it can be used in many R-22 systems without needing major component changes.

Why Switch from R-22 to R-422B?

The production and import of R-22 (HCFC-22) have been phased out in the United States and many other countries due to its ozone-depleting properties. As supply diminishes, prices have skyrocketed, and compliance with EPA regulations has become a priority for all HVAC-related businesses.

That’s where R-422B steps in.

Key Benefits of R-422B

✅ EPA-Approved – Fully compliant with EPA’s Clean Air Act guidelines.
✅ Ozone-Friendly – No chlorine content; does not deplete the ozone layer.
✅ Efficient Cooling Performance – Provides cooling capacity similar to R-22.
✅ No Oil Change Required – Compatible with mineral oil, alkylbenzene, and POE oils, saving time and labor.
✅ Safe to Use – Classified as A1; low toxicity and non-flammable.
✅ Quick Drop-In Replacement – Minimizes downtime during retrofits.

Applications of R-422B Refrigerant

R-422B is a versatile refrigerant suitable for both residential and commercial systems. It’s ideal for:

✔ Residential air conditioning units
✔ Light commercial HVAC systems
✔ Supermarket refrigeration systems
✔ Ice machines and vending equipment
✔ Cold storage warehouses

Its wide applicability makes it a go-to option for contractors looking to upgrade R-22 systems quickly and affordably.

Understanding the R-422B 25 lb Cylinder

At Royal Refrigerants, the R-422B 25 lb (NU22) Refrigerant New Factory Sealed Cylinder is one of the most popular sizes available. Here’s why:

🔹 Key Product Features

✔ Brand New – Factory sealed for guaranteed purity and performance.
✔ 25 lb Cylinder – Perfect size for medium to large service jobs.
✔ DOT-Approved Packaging – Safe and compliant for transport and storage.
✔ Color-Coded Cylinder – Easy to identify and handle on job sites.

Whether you’re servicing a residential split system or a commercial walk-in freezer, this size offers just the right amount of refrigerant for most service calls.

Compatibility with Existing Systems

One of the most attractive features of R-422B is its broad compatibility with existing equipment. This refrigerant can be used in:

✔ Older R-22 HVAC systems
✔ Units using mineral oil (MO) or alkylbenzene (AB)
✔ Systems that would require extensive changes to convert to other alternatives

No Oil Change Needed

Unlike some other R-22 replacements, R-422B can often be used without replacing the system's oil—reducing both material and labor costs.

R-422B vs Other R-22 Replacements

There are several alternatives to R-22 on the market, including R-407C, R-421A, and R-438A. So how does R-422B compare?

As shown, R-422B stands out as a cost-effective, low-hassle solution that doesn’t require oil conversion and delivers reliable performance.

Proper Handling and Storage Tips

To get the most out of your R-422B 25 lb refrigerant cylinder, follow these best practices:

✔️ Storage

✔ Keep in a cool, dry place away from direct sunlight.
✔ Store upright to prevent leakage.
✔ Use only approved storage cabinets for flammable or pressurized gases.

✔️ Handling

✔ Always wear gloves and eye protection.
✔ Charge the refrigerant as a liquid (not vapor) to ensure proper blend ratios.
✔ Avoid mixing with other refrigerants.

✔️ Safety Notes

✔ R-422B is non-toxic and non-flammable, but misuse can still cause harm.
✔ Follow EPA Section 608 guidelines for recovery and disposal.

FAQs About R-422B Refrigerant

Is R-422B a direct replacement for R-22?

Yes. R-422B is considered a drop-in replacement and is suitable for most R-22 systems without major modifications.

Do I need to change the oil in my system?

In most cases, no. R-422B is compatible with mineral oil, POE, and AB oils, allowing you to use it with existing oils.

Can I top off an existing R-22 system with R-422B?

No. You should fully evacuate the system of R-22 before adding R-422B to maintain performance and safety.

How do I know if R-422B is right for my application?

If you’re working with an older R-22 system and need a low-cost, fast retrofit, R-422B is likely your best option. Consult with your HVAC supplier or a certified technician for confirmation.

Why Buy R-422B from Royal Refrigerants?

With decades of experience and a commitment to quality, Royal Refrigerants is the trusted name in HVAC refrigerant supply.

🛒 Key Benefits of Buying from Royal Refrigerants

🚚 Fast Shipping Nationwide
✅ Factory-Sealed, Fresh Stock
💰 Competitive Pricing
☎️ Expert Customer Support
🔒 Secure Online Checkout

We understand the needs of HVAC pros and businesses. That’s why we stock only EPA-compliant, certified refrigerants, including the R-422B 25 lb cylinder—ready for immediate dispatch to your location.

Conclusion: Make the Switch to R-422B Today

The R-422B 25 lb (NU22) Refrigerant New Factory Sealed Cylinder is the smart solution for replacing R-22 without the headaches. It’s safe, efficient, and easy to use—saving you time and money while keeping your systems running smoothly.

Whether you're performing a retrofit or routine maintenance, R-422B offers the performance and peace of mind you need.

👉 Explore our full collection and place your order today at Royal Refrigerants.